A mental health app (TREE-Connect) with remote psychotherapy for late-life depression

You may qualify if

• Adults aged 50-80
• Capacity to provide consent for research assessment and treatment.
• Significant depression, i.e., PHQ-9 ≥ 7 (mild-moderate severity of symptoms)
• Mini Mental Status Exam (MMSE) equal or greater than a score of 23.
• Off antidepressants or on stable dose for 8 weeks and do not intend to change the dose in the next 10 weeks, without individual psychotherapy services during the study period.

You can't join if

• Intent or plan to commit suicide in the near future.
• Inability to communicate in English.
• History or presence of psychiatric diagnoses other than major depressive disorder without psychotic features, generalized anxiety disorder, specific phobia, or antisocial or borderline personality disorder.
• Neurological disorders (dementias, amnestic and multidomain Mild Cognitive Impairment, Parkinson's disease, epilepsy, etc.).
• Acute or severe medical illness in the past 3 months (metastatic cancer, multiple sclerosis, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction, cardiac, renal, or respiratory failure; severe chronic obstructive pulmonary disease, etc.) that may be the primary cause depressive symptoms, influence brain systems of interest, or impact ability to participate in the study.
• For MRI only: Contraindications to MRI scanning including cardiac pacemaker, heart valve replacement, vascular stent, insulin pump, cochlear implant, any other metallic biomedical implant contraindicating to MRI, and claustrophobia.