What this study is
The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if objective tasks that measure cognitive, emotional, and control aspects of resilience match up with self-reported resilience during stress and non-stress situations.
What's being tested
- Acute Stress Intervention (MAST-based)
Intervention · BEHAVIORAL
This intervention uses the Maastricht Acute Stress Test (MAST) to induce an acute stress response. Participants are exposed to standardized stress tasks while performing laboratory-based assessments of cognitive, emotional, and control aspects of resilience.
- Non-Stress Intervention (NST-based)
Intervention · BEHAVIORAL
In this control intervention, participants complete the same battery of laboratory tasks without exposure to the acute stressor.
Study details
- Official title
- A Novel Human Laboratory Model of Resilience Among Individuals With Opioid Use Disorder
- Sponsor
- Johns Hopkins University
- Conditions
- Opioid Use Disorder
- Enrolling
- 125 people
- Starts
- 2026-05-29
- Est. completion
- 2029-04-30
- Design
- Open-label, randomized, crossover
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Can provide informed consent and can comply with study procedures
- Adults aged ≥18 years
- Meet Diagnostic and Statistical Manual (DSM-5) criteria for current opioid use disorder or are currently receiving pharmacotherapy for the treatment of OUD (e.g. methadone or buprenorphine maintenance treatment [remission])
- Urine sample that tests positive for opioids
- Test negative for pregnancy at screening (females only)
You can't join if
- Being pregnant or breastfeeding
- Significant mental health or physical disorder, or life circumstances, that is judged by the investigators to interfere with study participation
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openJohns Hopkins University Bayview Medical Campus
Baltimore, Maryland, United States
Not yet recruitingJohns Hopkins University Bayview Medical Campus
Baltimore, Maryland, United States
- Alec Zhang, BS · Contact410-550-4121smart209@jh.edu
Recruiting
Study team
Sponsor
Johns Hopkins University
Study ID IRB00438915
Principal investigator
Suky Martinez, PhD
Johns Hopkins University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.