What this study is
This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms. Participants will be randomly assigned to one of two arms: the diet intervention arm or the "continue current diet"/control arm. Participants randomized to the dietary intervention arm will change their diet to follow a MIND dietary pattern for one year; diet-related education and programming is provided to support this change. Participants randomized to the continue/control arm will be asked to continue their current dietary habits, without major change for one year; multiple sclerosis (MS) MS-related related education and programming (unrelated to diet) is provided. All participants will be asked to provide blood \& stool samples and to complete online questionnaires \& three in-person assessments.
What's being tested
- Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet
Intervention · BEHAVIORAL
A dietary pattern which promotes the intake of olive oil, fish, leafy greens \& other vegetables, fruits, whole grains, and legumes, and discourages processed foods, red meat, and sugar.
- Small Group
Intervention · BEHAVIORAL
Education and social support on topics related to multiple sclerosis such as disease-modifying therapies and MRI in MS.
Study details
- Official title
- Randomized Controlled Trial of MIND Diet for Neuroprotection and Symptom Management in MS
- Sponsor
- Icahn School of Medicine at Mount Sinai
- Conditions
- Multiple Sclerosis
- Enrolling
- 100 people
- Starts
- 2025-07-16
- Est. completion
- 2029-04-30
- Design
- Single-blind, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 70 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Ages 18-70 years, inclusive
- MS diagnosis, on any treatment (including no treatment)
- MIND diet score of ≤9 at baseline
You can't join if
- Diagnosis of an additional neurodegenerative disease (e.g. Alzheimer's) or other serious neurological condition (e.g. stroke)
- Current serious medical condition that could impact the ability to participate or influence study results (e.g. cancer, HIV)
- Pregnancy/planning during study period
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openMount Sinai Hospital
New York, New York, United States
- Ilana B Katz Sand, MD · Contact212-241-6854ilana.katzsand@mssm.edu
- Ilana B Katz Sand · Principal investigator
Recruiting
Study team
Sponsor
Icahn School of Medicine at Mount Sinai
Study ID GCO 23-0300
Principal investigator
Ilana B Katz Sand, MD
Icahn School of Medicine at Mount Sinai
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.