What this study is
In this observational cohort study, the researchers propose to first identify a psychophysiological marker of methamphetamine cue-reactivity and its incubation with abstinence from methamphetamine use (MUD) and examine group-differences between men who have sex with men (MSM) and non-MSM MUD.
The primary objective is to identify psychophysiological markers of methamphetamine (MA) cue-reactivity and its abstinence incubation. The secondary objective is to examine group-differences in methamphetamine use disorder (MUD) individuals between homosexual men (MSM) and heterosexual men (non-MSM). The primary endpoint is to assess incubation of cue-reactivity longitudinally with its reduction in cognitive reappraisal, and the secondary endpoint is to examine the impact of cognitive reappraisal on clinical outcomes of methamphetamine use disorder (MUD) in homosexual men (MSM).
2-year long study. Screening and enrollment will be done at different locations of the Addiction Institute of Mount Sinai. The EEG session will be done at Icahn School of Medicine at Mount Sinai. Participation in the research study will be for a single EEG session.
What's being tested
- Cognitive Reappraisal
Intervention · BEHAVIORAL
an emotion-regulation strategy while being asked to complete cognitive tasks.
Study details
- Official title
- Cue Reactivity Modulation in MSM With Methamphetamine Use Disorder
- Sponsor
- Icahn School of Medicine at Mount Sinai
- Conditions
- Methamphetamine Use Disorder
- Enrolling
- 88 people
- Starts
- 2024-08-19
- Est. completion
- 2025-08-30
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 60 YearsSex MALEHealthy volunteers Not acceptedYou may qualify if
- Ability to understand and give informed consent
- Identify as either MSM or non-MSM
- Males; Age 18-60
- DSM-5 Diagnosis of MUD (Methamphetamine Use Disorder)
- Have appropriate abstinence duration [i.e., current Methamphetamine users (MA): 2 weeks (range: 1-3 weeks); MA-abstinent: 3 months (range: 2-4 months)]
- Treatment-seeking MUD must be in a treatment facility for substance use disorder, with MA as the primary drug (at the first visit)
- Treatment-seeking MUD must be abstinent from MA use for approximately 2 weeks (range: 1-3 weeks) at enrollment.
You can't join if
- Women
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openIcahn School of Medicine at Mount Sinai
New York, New York, United States
- Muhammad A Parvaz, PhD · Contact212-241-3638muhammad.parvaz@mssm.edu
- Muhammad A Parvaz · Principal investigator
Recruiting
Study team
Sponsor
Icahn School of Medicine at Mount Sinai
Study ID STUDY-20-00284
Principal investigator
Muhammad A Parvaz, PhD
Icahn School of Medicine at Mount Sinai
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.