What this study is
Freezing of gait - the inability to start or continue walking - is a particularly disabling problem in Parkinson's disease that has few treatment options. This project records human brain activity from deep brain stimulation (DBS) devices during walking and freezing of gait episodes to understand the pathophysiology of freezing of gait. Findings will lay the foundation for the development of new treatment strategies that address this disabling symptom.
What's being tested
- VR Freezing Task
Intervention · BEHAVIORAL
Walking overground in immersive virtual reality (VR) environments that provoke freezing episodes
- Dual Task
Intervention · BEHAVIORAL
Walking overground with and without concomitant performance of secondary cognitive or motor task
- External Cueing
Intervention · BEHAVIORAL
Walking overground in immersive virtual reality (VR) environments that provoke freezing episodes with and without addition of visual and auditory cues.
Study details
- Official title
- Leveraging Invasive Recordings and Immersive Virtual Reality to Characterize Freezing of Gait Mechanisms in Parkinson Disease
- Sponsor
- University of California, Los Angeles
- Conditions
- Parkinson&Amp;#39;s Disease · Freezing of Gait · Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease
- Enrolling
- 36 people
- Starts
- 2025-11-01
- Est. completion
- 2030-03
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Patients meeting the MDS clinical diagnostic criteria for Parkinson's disease who are implanted with a Medtronic Percept DBS Device and SenSight Directional Leads in bilateral globus pallidus internus (GPi).
- Able to walk unassisted indoors
- Age 18 or older
- Half of patients will have disabling freezing of gait as defined by freezing more than once per day by self-report on questions 1 & 2 of the New Freezing of Gait Questionnaire
- The other half of patients will not have freezing of gait as defined by self-report on question 1 of the New Freezing of Gait Questionnaire
You can't join if
- Clinical diagnosis of dementia or severe cognitive impairment (MOCA < 21)
- History of stroke, traumatic brain injury, or other neurologic disorders besides Parkinson's disease
- Comorbidities causing severe gait impairments
- Unstable medical condition including cardio-vascular instability in the past 6 months
- Unable or unwilling to comply with the testing protocol
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of California, Los Angeles
Los Angeles, California, United States
Study team
Sponsor
University of California, Los Angeles
Study ID 24-5770
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.