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Muscle WeaknessExercise and fitnessDeviceBehavioral

What this study is

Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife.

The main questions it aims to answer are:

What changes happen in the nervous system that lead to weakness when a wrist is immobilized?

Can training the opposite arm help maintain muscle strength, muscle size, and nervous system function in the immobilized arm?

Researchers will compare women who have their wrist immobilized with or without opposite-arm resistance training.

Participants will:

Wear a wrist cast on one arm for 7 days

Complete strength training with the opposite arm or no training, depending on their group

Attend study visits for strength and nervous system testing

Have non-invasive tests (like magnetic brain stimulation, muscle recordings, and muscle imaging) to measure how the nervous system and muscle responds

What's being tested

  • Wrist immobilization

    Intervention · DEVICE

    The wrist immobilization will use a medical device (wrist cast) to immobilize the left, non-dominant wrist for 7 days.

  • Resistance training

    Intervention · BEHAVIORAL

    The cross-education intervention will consist of resistance training on the dominant hand.

  • Resistance training rehabilitation

    Intervention · BEHAVIORAL

    The resistance training rehabilitation will occur for the non-dominant hand following the immobilization phase for all participants.

Study details

Sponsor
Kansas State University
Conditions
Muscle Weakness
Enrolling
20 people
Starts
2026-05-01
Est. completion
2027-01-31
Design
Single-blind, randomized, parallel groups
Record
View on ClinicalTrials.gov ↗