What this study is
This study aims to evaluate long-term outcomes when the etonogestrel contraceptive implant is inserted at an alternative site located over the scapular. The study will evaluate the pharmacokinetics (i.e., drug levels) and side effect profiles of participants who have an etonogestrel contraceptive implant inserted at this alternative scapular site over the course of at least two years.
What's being tested
- Scapular-site insertion of etonogestrel contraceptive implant
Intervention · DRUG
Participants will undergo insertion of the etonogestrel contraceptive implant subdermally over the inferior edge of their non-dominant scapula
Study details
- Official title
- Prospective Long-term Study of Etonogestrel Contraceptive Implant Insertion at an Alternative Scapular Site
- Sponsor
- Yale University
- Conditions
- Contraception
- Enrolling
- 62 people
- Starts
- 2026-05-08
- Est. completion
- 2029-05-31
- Design
- Open-label, single group, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 45 YearsSex FEMALEHealthy volunteers AcceptedYou may qualify if
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Sex assigned at birth must be Female
- Aged 18-45 years
- In good general health as evidenced by medical history and no need for regular intensive medical interventions (e.g., inpatient admissions, surgical treatments). The Principal Investigator will be responsible for determining good general health for potential participants with complicated medical histories
- Interest and willingness to use an etonogestrel contraceptive implant
- Negative pregnancy test at the time of study enrollment and not planning to become pregnant in the next 36 months
- Willing to abstain from medications and supplements known to induce/inhibit CYP3A (e.g., rifampin, carbamazepine, ketoconazole, St. John's wort) during the study. In the inducer/inhibitor CYP3A medication is a prescribed medication, individuals must provide the prescriber information for the PI to confirm it is safe for this medication to be abstained during the study
- Body-mass index ≥18.5kg/m2
You can't join if
- Self-reported contraindications to the use of the ENG implant based on the CDC Medical Eligibility Criteria guidelines for any conditions with a category 3 or 4 recommendation; Current breast cancer or personal history of breast cancer; Malignant liver tumor (hepatocellular carcinoma); Allergic reaction to any components of the ENG implant
- Any self-reported known liver conditions that could affect drug metabolism (e.g., cirrhosis, hepatitis)
- Personal history of deep vein thrombosis (DVT), venous thromboembolism (VTE), or arterial thromboembolism (ATE).
- Currently taking and unable or unwilling to abstain from any medications or supplements known to be CYP3A inducers/inhibitors.
- Current use of a progestin-only contraceptive method containing desogestrel or etonogestrel
- History of spinal deformity (e.g., kyphosis, lordosis)
- History of shoulder or scapular surgery on the non-dominant side
- Non-dominant shoulder mobility limitations
- Previous trauma to the non-dominant scapular region
- Active skin conditions (e.g., psoriasis) in the non-dominant scapular region
- Inability to palpate the bony landmarks of the scapula due to adiposity or other body habitus
- Allergy to lidocaine
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openUniversity of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
- Cara Clure, MD, MS · Contact303-724-5000cara.clure@cuanschutz.edu
- Ashley Oltman · Contact303-704-6127ashley.oltman@cuanschutz.edu
- Cara Clure, MD · Principal investigator
RecruitingYale University School of Medicine
New Haven, Connecticut, United States
- Aaron Lazorwitz, MD, PhD · Contact203-737-7962aaron.lazorwitz@yale.edu
Recruiting
Study team
Sponsor
Yale University
Study ID 2000040944
Principal investigator
Aaron Lazorwitz, MD
Yale University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.