Tobacco-flavored ECAddictionMental healthBehavioralBehavioral
What this study is
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine
What's being tested
- Brief individual counseling sessions
Intervention · BEHAVIORAL
Five brief, individual counseling sessions will provide education, behavioral support, and motivational strategies to facilitate switching from combustible cigarette use to EC
Study details
- Sponsor
- Prisma Health-Upstate
- Conditions
- Tobacco-flavored EC · Sweet-Cooling EC · Sweet Non-cooling EC
- Enrolling
- 90 people
- Starts
- 2026-04-29
- Est. completion
- 2029-06-29
- Design
- Open-label, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 21 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Age ≥21 years
- Smoke ≥5 CPD for ≥1 year
- Daily CC smoker
- Willing to switch to EC
- Exhaled CO ≥6 ppm
- Diagnosed with OUD
- Stable on bupropion treatment
- In good physical and mental health
- Able to use a smartphone
- Willing to participate in all study components
- Able to provide informed consent
You can't join if
- Interested in quitting CC (contemplation stage of change)
- Use of EC on ≥4 of the past 30 days
- Use of other tobacco products (e.g., cigars, smokeless tobacco) on ≥9 days of the past 30 days
- Use of nicotine replacement therapy, smoking cessation medication, or a cessation attempt in the past 30 days
- Hypertension
- Medical condition that would contraindicate participation
- Meet DSM-V criteria for major depressive episode, psychotic episode, or manic episode
- Current suicidal ideation or suicide attempt in the past year
- Psychiatric hospitalization in the past year
- Contemplating pregnancy, currently pregnant, or breastfeeding
- Unable to speak and/or read English
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
Loading treatment details…
1
Study locations (1)
1 openAddiction Medicine Center
Greenville, South Carolina, United States
- Alain Litwin, MD · Contact864-455-5648alain.litwin@prismahealth.org
Recruiting
Study team
Sponsor
Prisma Health-Upstate
Study ID 2328661-1
Have questions? The contacts above can answer them before you apply.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.