What this study is
The thalamus plays a key role in supporting sleep and is also a target of therapeutic stimulation. This project investigates when, where, and how electrical stimulation delivered to the thalamus in humans elicits or disrupts sleep oscillations. This research is a first step to better understand how current neuromodulation therapies affect sleep and may help advance toward new therapies to improve sleep for a wide range of neurological and neuropsychological disorders.
What's being tested
- Effect of Electrical Stimulation on Sleep
Intervention · BEHAVIORAL
Direct electrical stimulation of thalamic nuclei and cortical structures using clinically implanted depth electrodes will allow assessing the effect of stimulation on sleep oscillations.
Study details
- Official title
- Thalamocortical Interactions and the Effect of Thalamic Stimulation on Sleep Oscillations
- Sponsor
- Massachusetts General Hospital
- Conditions
- Sleep · Neuromodulation
- Enrolling
- 50 people
- Starts
- 2025-01-06
- Est. completion
- 2029-11-30
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 5 Years – 85 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Patients getting intracranial recordings for clinical purposes who, as part of that plan, will receive thalamic electrodes.
You can't join if
- Previous extensive resection or large atrophy
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openBrigham and Women's Hospital
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Study team
Sponsor
Massachusetts General Hospital
Study ID 2007P000165-1R01AG090302
Principal investigator
Rina Zelmann, Ph.D.
Massachusetts General Hospital
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.