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Primary Progressive Aphasia(PPA)BehavioralBehavioral

What this study is

The goal of this clinical trial is to determine whether individually tailored speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will be offered to individuals who speak English and/or Spanish. The study will also document how acceptable and beneficial the program is to both patients and their care partners.

The main questions the study aims to answer are:

1. Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners? 2. Do participants with PPA and care partners find treatment beneficial? 3. Which outcome measures are most useful for evaluating changes in communication and quality of life? 4. What patterns of treatment response are seen in participants after completing the program?

The program includes both speech-language therapy and training for care partners.

Participants with PPA will:

1. Complete virtual communication tasks and questionnaires before and after the program 2. Take part in online speech-language therapy sessions 3. Include their care partners in some parts of the program for training and support

What's being tested

  • Multicomponent Lexical Retrieval Training

    Intervention · BEHAVIORAL

    In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Biweekly (approximately one hour each) sessions with a clinician target multimodal communication and the use of strategies to support word retrieval. These skills are also trained via daily independent practice. The participant meets four times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

  • Multicomponent Video Implemented Script Training in Aphasia

    Intervention · BEHAVIORAL

    In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Treatment focuses on production of individually-tailored, personally relevant scripts. The participant completes 30 minutes per day of independent practice, during which they speak in unison with a video model. Biweekly (approximately one hour each) sessions with a clinician target clear and accurate script production, memorization, and conversational usage, as well as multimodal communication. The participant meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

Study details

Official title
Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial
Sponsor
University of Texas at Austin
Conditions
Primary Progressive Aphasia(PPA) · Semantic Dementia · Logopenic Progressive Aphasia (LPA) · Nonfluent Aphasia, Progressive · Progressive Aphasia · Semantic Variant Primary Progressive Aphasia (svPPA) · Semantic Aphasia · Logopenic Variant Primary Progressive Aphasia · Logopenic Variant of Primary Progressive Aphasia (LPA) · Logopenic Progressive Aphasia · Nonfluent Variant Primary Progressive Aphasia (nfvPPA) · Nonfluent Progressive Aphasia
Enrolling
25 people
Starts
2026-01-03
Est. completion
2027-08
Design
Open-label, randomized, parallel groups
Record
View on ClinicalTrials.gov ↗