What this study is
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited.
This study seeks to develop a multi-omics-based liquid biopsy assay, especially focusing on ncRNAs (e.g. tsRNA, miRNA, circRNA, lncRNA, etc.) for accurate detection of early-stage HCC.
What's being tested
- Small RNA sequence
Intervention · DIAGNOSTIC TEST
Comprehensive small RNA sequencing of serum or plasma-derived cf-tsRNAs to identify candidate biomarkers distinguishing HCC from NDC.
- Rt-qPCR
Intervention · DIAGNOSTIC TEST
Construction of integrated cf- tsmiRNAs diagnostic classifier using machine learning
- Rt-qPCR
Intervention · DIAGNOSTIC TEST
PCR-based validation of the tsRNA panel
Study details
- Sponsor
- City of Hope Medical Center
- Conditions
- Hepatocellular Carcinoma (HCC)
- Enrolling
- 600 people
- Starts
- 2025-01-15
- Est. completion
- 2028-06-18
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers AcceptedYou may qualify if
- Adults aged 18 to 100 years.
- A histologically confirmed diagnosis of hepatocellular carcinoma.
- A clinically diagnosed as chronic liver disease, including chronic hepatitis or liver cirrhosis, without evidence of hepatocellular carcinoma.
- Healthy volunteers without known liver disease or malignancy.
- Received standard diagnostic and staging procedures as per local guidelines
- Availability of blood or other biospecimens.
- Ability to provide written informed consent.
You can't join if
- Lack of or inability to provide informed consent
- History of other active malignancies within the past 5 years
- Previous liver transplantation
- Severe systemic infection or inflammatory disease at the time of enrollment
- Inadequate sample quality or quantity
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openCity of Hope Medical Center
Duarte, California, United States
- Ajay Goel, PhD · Contact626-218-3452ajgoel@coh.org
Recruiting
Study team
Sponsor
City of Hope Medical Center
Study ID 23228/CENTINEL
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.