What this study is
The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Pumitamig in participants with Relapsed/Refractory Small Cell Lung Cancer
What's being tested
- BMS-986525
Intervention · DRUG
- Pumitamig
Intervention · DRUG
Both interventions
Specified dose on specified days
Study details
- Official title
- A Phase 1/2 Study of BMS-986525 as Monotherapy and in Combination Therapy in Participants With Relapsed/Refractory Small Cell Lung Cancer
- Sponsor
- Bristol-Myers Squibb
- Conditions
- Relapsed/Refractory Small Cell Lung Cancer
- Enrolling
- 240 people
- Starts
- 2026-02-03
- Est. completion
- 2029-04-24
- Design
- Open-label, non-randomized, parallel groups, Phase 1, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Participants must have histologically or cytologically documented relapsed/refractory small cell lung cancer (R/R-SCLC).
- Participants must have received at least 1 platinum-based chemotherapy regimen as per locally approved drug labels and institutional guidelines.
- In countries where standard of care first line systemic treatment includes platinum containing chemotherapy in combination with anti-PD-(L)1 therapy, it is required that participants have progressed on, are ineligible for or not have access to an anti-PD- (L)1 therapy.
You can't join if
- Participants must not have any untreated CNS metastases.
- Participants must not have an active, known or suspected autoimmune disease.
- Participants must not have had a prior organ or tissue allograft.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (13)
13 openKarmanos Cancer Institute
Detroit, Michigan, United States
- Hirva Mamdani, Site 0011 · Contact313-576-8711
RecruitingRoswell Park Cancer Institute
Buffalo, New York, United States
- Prantesh Jain, Site 0026 · Contact716-845-3099
RecruitingDuke Cancer Institute
Durham, North Carolina, United States
- Neal Ready, Site 0005 · Contact919-681-7460
RecruitingUniversity Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
- Afshin Dowlati, Site 0004 · Contact216-844-5432
RecruitingSCRI Oncology Partners
Nashville, Tennessee, United States
- Melissa Johnson, Site 0006 · Contact615-329-7274
Recruiting
8 sites outside the US
Local Institution - 0029
Beijing, Beijing Municipality, China
- Site 0029 · Contact
Not yet recruitingShanghai East Hospital
Shanghai, Shanghai Municipality, China
- Caicun Zhou, Site 0028 · Contact8613301825532
Recruiting- Recruiting
Local Institution - 0020
Hirakata, Osaka, Japan
- Site 0020 · Contact
Not yet recruitingLocal Institution - 0018
Chuo-ku, Tokyo, Japan
- Site 0018 · Contact
Not yet recruitingOncohelp Medical Center
Timișoara, Timiș County, Romania
- Cristina Oprean, Site 0023 · Contact+40745148485
RecruitingCentrul de Oncologie Sf. Nectarie SRL
Craiova, Romania
- Michael Schenker, Site 0003 · Contact40727774974
RecruitingHospital Universitario 12 de Octubre
Madrid, Spain
- Luis Paz-Ares Rodriguez, Site 0009 · Contact0034913908922
Recruiting
Study team
Sponsor
Bristol-Myers Squibb
Study ID CA258-0001
Study director
Bristol-Myers Squibb
Bristol-Myers Squibb
CONTACT
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
First line of the email MUST contain NCT # and Site #.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.