What this study is
Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming. This study will evaluate physiology-based programming using local field potentials (LFPs) to identify optimal stimulation parameters. Specifically, DBS contact selection based on beta power and a broad-band approach will be compared with conventional clinician-based programming.
What's being tested
- Clinician-based DBS programming
Intervention · DEVICE
Contacts, amplitude, pulse width, and frequency are chosen by the treating physician during a conventional monopolar review.
- Maximum Beta power-based DBS programming
Intervention · DEVICE
The contact that shows the strongest beta activity (13-30 Hz) in the local field potentials is selected for stimulation.
- Broad-band electrophysiology-based DBS programming
Intervention · DEVICE
A multi-frequency algorithm that integrates beta, theta/alpha, finely tuned gamma, and other relevant bands is used to identify the optimal contact.
Study details
- Official title
- Electrophysiology-based Deep Brain Stimulation Programming for Parkinson's Disease
- Sponsor
- University of Florida
- Conditions
- Parkinson's Disease (PD)
- Enrolling
- 30 people
- Starts
- 2026-01-15
- Est. completion
- 2031-01-15
- Design
- Single-blind, randomized, crossover
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 21 Years – 89 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Patients with a diagnosis of idiopathic PD fulfilling the Movement Disorder Society Clinical Diagnostic Criteria for PD
- DBS implantation with the Percept DBS device (Medtronic, USA) for the treatment of motor symptoms
- Ability to give informed consent for the study
- Willingness to do this study at the time of the initial programming session
- Age 21 to 89 years old
You can't join if
- Inability to comply with the study protocol
- Atypical Parkinsonism
- Any personality or mood symptoms that study personnel believe will interfere with the study requirements
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openNorman Fixel Institute for Neurological Diseases
Gainesville, Florida, United States
- Hikaru Kamo, MD, PhD · ContactHikaru.Kamo@neurology.ufl.edu
- Julia C Gonzalez, BA · ContactJulia.Gonzalez@neurology.ufl.edu
- Joshua Wong, MD · Principal investigator
- Hikaru Kamo, MD, PhD · Sub-investigator
Recruiting
Study team
Sponsor
University of Florida
Study ID IRB202500821
Principal investigator
Joshua Wong, MD
University of Florida
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.