What this study is
The goal of this clinical trial is to use a modified thermal probe to measure temperature rise in the colonic mucosa of participants with inflammatory bowel disease, Crohn's disease, and/or ulcerative colitis. The main question it aims to answer is:
Is the thermal probe an effective device to use to detect temperature rise in the colonic mucosa?
During the participant's standard of care colonoscopy, the thermal probe will be inserted into the colonoscope. The thermal probe is connected to a temperature transmitter that collects and saves the temperature of the colon in real time.
What's being tested
- Feasibility of using a thermal probe to measure temperature rise in colonic mucosa
Intervention · DEVICE
10 participants in each arm will be enrolled in this study. All consented participants will receive the same intervention.
Study details
- Official title
- Colonoscopic Investigation of the Correlation Between Bowel Wall Inflammation and Luminal Temperature Rise in IBD
- Sponsor
- Massachusetts General Hospital
- Conditions
- Inflammatory Bowel Diseases · Crohn Disease · Ulcerative Colitis
- Enrolling
- 20 people
- Starts
- 2026-03-25
- Est. completion
- 2029-12
- Design
- Open-label, non-randomized, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Participants 18 years or older
- Participants undergoing elective colonoscopy
- Participants capable of following requirements
- Participants capable of providing informed consent
- Participants with a diagnosis of IBD, Crohn's disease, and/or ulcerative colitis or participants undergoing colorectal cancer screening
You can't join if
- Participants contraindicated for colonoscopy, including experiencing acute events within the last 6 weeks prior to the colonoscopy (i.e. subjects suffering from a myocardial infarction (heart attack), diagnosis of peritonitis (the inflammation of the membrane lining of the abdominal wall), diagnosis of hemodynamic instability (shock), surgery involving colonic anastomosis (reconnection of the colon), and/or bowel injury (from trauma or surgery)
- Participants who are pregnant
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openMassachusetts General Hospital
Boston, Massachusetts, United States
Study team
Sponsor
Massachusetts General Hospital
Study ID 2025P000709
Principal investigator
Guillermo Tearney, M.D., PhD
Massachusetts General Hospital
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.