How liver damage affects blood levels of a drug, eloralintide (LY3841136)

You may qualify if

• Have a body weight of 55 kilograms (kg) or more and body mass index between 19.0 and 40.0 kilograms per square meter (kg/m²), inclusive Group 1
• Are healthy as determined by medical history, physical examination, and other screening procedures, with clinically normal hepatic function at screening Groups 2 through 4
• Have hepatic impairment classified as Child-Pugh score A, B, or C (mild, moderate, or severe impairment who are considered acceptable for participation in this study by the investigator. Participants must have a diagnosis of chronic hepatic impairment of greater than 6 months per physician diagnosis and standard-of-care practice, with no clinically significant changes in the opinion of the investigator within 15 days prior to screening Participants with hepatic impairment may have stable baseline medical conditions for which neither the condition nor treatments received would negatively impact the health of the participant or study conduct

You can't join if

• Have a history or presence of chronic or acute pancreatitis or elevation in serum amylase or lipase greater than 1.5 × upper limit of normal (ULN)
• Are pregnant or intend to become pregnant or to breastfeed during the study Group 1
• Have liver disease, obvious clinical signs or symptoms of liver disease, acute or chronic hepatitis, or have elevations in aspartate aminotransferase (AST) or alanine transaminase (ALT) greater than 1.5 × ULN or total bilirubin (TBL) greater than 1.5 × ULN at screening
• Have a current infection with hepatitis B virus (HBV), that is,; if hepatitis B surface antigen (HBsAg) is positive, the participant is excluded, or; if HBsAg is negative and anti-Hepatitis B core antibody (HBc) is positive, further testing for HBV deoxyribonucleic acid (DNA) is required, and; if the screening HBV DNA is positive, the participant is excluded
• Have a current infection with hepatitis C virus (HCV), that is,; if anti-HCV is positive, a test for circulating HCV ribonucleic acid (RNA) is required, and; if HCV RNA test is positive, the participant is excluded Groups 2, 3, and 4
• Have presence of active portal shunt or transjugular intrahepatic portosystemic shunt
• Require paracentesis more often than 2 times per month or are expected to require paracentesis during the study
• Have evidence of spontaneous bacterial peritonitis within 6 months of screening
• Have had variceal bleeding within 3 months of screening. If the participant has undergone a successful banding procedure, they may participate in the study providing at least 1 month has passed after the banding procedure at the time of screening
• Show presence of hepatocellular carcinoma
• Have hepatic encephalopathy of Grade 2 or higher
• Have TBL greater than 15 milligrams per deciliter (mg/dL)
• Have ALT greater than or equal to 6 × ULN