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Retinitis PigmentosaRare diseaseGeneticsFirst-in-humanVision and hearingDrugPhase 1, Phase 2

What this study is

This integrated Ph1/2 clinical study is to assess the safety, tolerability and pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of OCT-980 in healthy volunteers and participants with RHO-adRP.

What's being tested

  • Phase 1b/2: Cohort 1 - OCT-980 Tablet

    Intervention · DRUG

  • Phase 1b/2: Cohort 2 - OCT-980 Tablet

    Intervention · DRUG

  • Phase 1b/2: Cohort 3 - OCT-980 Tablet

    Intervention · DRUG

  • Phase 1b/2: Cohort 4 - OCT-980 Tablet

    Intervention · DRUG

  • Phase 1b/2: Cohort 5 - OCT-980 Tablet

    Intervention · DRUG

All interventions

OCT-980 tablets administered orally once daily at dose levels specified in the protocol

Study details

Official title
A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of OCT-980 in Healthy Volunteers and Participants With Autosomal Dominant Retinitis Pigmentosa
Sponsor
Octant, Inc.
Conditions
Retinitis Pigmentosa
Enrolling
18 people
Starts
2026-03-10
Est. completion
2028-11-01
Design
Open-label, non-randomized, sequential groups, Phase 1, Phase 2
Record
View on ClinicalTrials.gov ↗