What this study is
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
What's being tested
- Neurophysiology recordings
Intervention · OTHER
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
- Neural stimulation
Intervention · OTHER
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Study details
- Sponsor
- Vanderbilt University Medical Center
- Conditions
- Parkinson Disease
- Enrolling
- 75 people
- Starts
- 2024-09-01
- Est. completion
- 2029-09-30
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 40 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
- Planned clinical electrode trajectory that contacts caudate
- Age greater than or equal to 40
- Diagnosis of Parkinson's disease or other movement disorder
- Able to participate in intraoperative testing
- English speaking
You can't join if
- Age less than 40
- Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openVanderbilt University Medical Center
Nashville, Tennessee, United States
- Lucas Chang, BA · Contact615-421-3046lucas.m.chang@vumc.org
- Sarah Bick, MD · Principal investigator
Recruiting
Study team
Sponsor
Vanderbilt University Medical Center
Study ID K08NS140767
Principal investigator
Sarah Bick
Vanderbilt University Medical Center
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.