What this study is
This pilot randomized clinical trial will evaluate the feasibility, acceptability, and preliminary effectiveness of immersive Virtual Reality (VR) nature intervention among adults with at least moderate depression symptoms enrolled in an intensive outpatient Program (IOP) for Alcohol Use Disorder (AUD).
The study hypotheses:
- VR-based nature immersion will be feasible, acceptable, and positively evaluated by participants
- Participants receiving the VR intervention will report greater reductions in symptoms of depression, anxiety, and stress compared to those receiving standard care alone
What's being tested
- Virtual Reality (VR) -nature treatment
Intervention · DEVICE
Participants assigned to the VR intervention will engage in 5 to 30-minute (gradual increase in duration as tolerated to prevent motion sickness) -3 times per week, immersive VR nature sessions over 4 weeks, using the Apple Vision Pro and Explore POV app, alongside standardintensive outpatient program (IOP) care or other treatments they are receiving (e.g., additional counseling, psychiatry, etc.).
- Survey completion
Intervention · BEHAVIORAL
All participants will complete surveys at various time-points (baseline - 9 weeks).
Study details
- Official title
- Virtual Reality Nature Immersion to Reduce Depression in People Engaged in Intensive Outpatient Alcohol Treatment
- Sponsor
- University of Michigan
- Conditions
- Alcohol Use Disorder
- Enrolling
- 50 people
- Starts
- 2026-02-16
- Est. completion
- 2028-02
- Design
- Open-label, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Individuals with a documented AUD diagnosis
- Individuals enrolled in an Intensive Outpatient Program (IOP) (First week enrollment or planned enrollment in Michigan Medicine's Addiction Treatment Services (UMATS) IOP)
- Individuals with a Patient Health Questionnaire (PHQ-9) score (≥10, moderate or greater depression symptoms)
You can't join if
- Severe motion sickness or sensitivity to VR-induced nausea or dizziness (anticipated <10%), medical contraindications to VR use (e.g., seizure disorders, vestibular disorders, agoraphobia, claustrophobia, psychosis).
- Significant cognitive impairments that prevent provision of informed consent
- Suicidal ideation or plan after consultation with treating clinician
- Participants who require vision correction with glasses, unless vision correction is mild (±1), or the participant does not have prescription contact lenses.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of Michigan
Ann Arbor, Michigan, United States
- Zee Petrie · Contact734-647-3357petrieli@med.umich.edu
- Hala Darwish, PhD · Principal investigator
Recruiting
Study team
Sponsor
University of Michigan
Study ID HUM00283019
Principal investigator
Hala Darwish, PhD
University of Michigan
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.