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Chronic PancreatitisDiagnostics and screeningDrugDiagnostic testPhase 4

What this study is

This project uses the Malabsorption Blood Test (MBT) to identify patients with recurrent acute or chronic pancreatitis who have mild to moderate exocrine pancreatic insufficiency. A subgroup of patients who have response to pancreatic enzyme replacement therapy will enter a randomized, placebo-controlled pilot clinical trial for 8 weeks to identify improvements in quality of life (QOL).

What's being tested

  • Pancreatic Enzyme Replacement Therapy

    Intervention · DRUG

    12 participants who are PERT responders in the MBT will be randomized to receive 8 weeks of PERT (144,000 lipase units daily)

  • Placebo

    Intervention · DRUG

    12 participants who are PERT responders in the MBT will be assigned to receive 8 weeks of placebo therapy

  • MBT1

    Intervention · DIAGNOSTIC TEST

    MBT off PERT

  • MBT 2

    Intervention · DIAGNOSTIC TEST

    MBT on PERT

Study details

Sponsor
Anna Evans Phillips
Conditions
Chronic Pancreatitis · Recurrent Acute Pancreatitis · Exocrine Pancreatic Insufficiency
Enrolling
80 people
Starts
2026-04-20
Est. completion
2028-09
Design
Triple-blind, randomized, sequential groups, Phase 4
Record
View on ClinicalTrials.gov ↗