What this study is
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
What's being tested
- Snack Type 1: Walnuts
Intervention · OTHER
Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team.
- Snack Type 2: Pretzels
Intervention · OTHER
Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team.
Study details
- Sponsor
- University of Colorado, Denver
- Conditions
- Overweight/Obesity
- Enrolling
- 70 people
- Starts
- 2026-03-05
- Est. completion
- 2028-03-31
- Design
- Double-blind, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 25 Years – 45 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- 25-45 years old
- BMI at least 27 kg/m2
- Comfortable completing a weight-loss intervention
- Willing to consume a daily snack of either walnuts or pretzels
You can't join if
- Nut or wheat allergy
- History of bariatric surgery
- Current eating disorder
- Current illicit substance use
- Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum
- Uncontrolled hypertension (>160/100 mmHg)
- Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results
- Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment
- Taking weight-loss medications, or steroids within ~3 months prior to study participation (e.g., GLP-1 receptor agonists)
- Significant mental health changes within ~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns)
- Neurological illnesses or injury that would be anticipated to affect MRI data
- Weight change greater than 10% within 3 months prior to study participation
- Currently participating in another weight-loss study
- Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan)
- MRI-specific exclusion criteria (e.g., metal in the body, weight >500 lbs
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
- Kristina Legget, PhD · Contact303-724-5809kristina.legget@cuanschutz.edu
- Allison Hild, BS · Contact303-724-9024allison.hild@cuanschutz.edu
- Kristina T Legget, PhD · Principal investigator
Recruiting
Study team
Sponsor
University of Colorado, Denver
Study ID 25-1900
Principal investigator
Kristina T Legget, PhD
University of Colorado, Denver
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.