An omega-3 marine lipid supplement for chronic jaw and facial pain

You may qualify if

• Pre-screening (before Visit 0):; Age ≥18 years.; Pain in jaws, temples, ears, or in front of ears at least 5 days in the past 30 days, occurring monthly over the last 3 months.; Pain not due to toothache or ear infection.; Pain intensity ≥30 on a 0-100 numeric rating scale (NRS) during the week before pre-screening.; Willing to provide written informed consent and follow all study procedures.; Able to be contacted reliably during the study period. Visit 0 - Screening/Baseline:; Meets all pre-screening criteria above.; Examiner-confirmed TMD diagnosis (myalgia or arthralgia) per DC-TMD criteria.; Discontinues omega-3 supplements prior to randomization and agrees not to use them during the study.; Will not initiate new occlusal splint therapy during the study. Participants already using a splint ≥30 days prior may continue.; Maintains stable facial pain management regimen:; No changes to regularly scheduled daily pain medications.; No initiation of new facial pain treatments (pharmacologic, injectable, or non-pharmacologic).; Episodic prescription pain medications discontinued prior to randomization, except NSAIDs, acetaminophen, or low-dose aspirin. Visit 1 - Randomization:; Completes ≥4 of 7 daily symptom diary (DSD) entries before Visit 1.; Average weekly pain ≥30 on 0-100 NRS, or ≥30 on at least 4 days that week. Exclusion (Assessed at pre-screening and/or Visit 0):; Allergy or hypersensitivity to fish or seafood.; Botulinum toxin injections for facial pain within past 3 months.; Facial trauma or orofacial surgery within past 6 weeks.; History of renal failure or dialysis.; History of hyperthyroidism.; Immunocompromised state or autoimmune disorder.; History of seizure disorder or uncontrolled seizures.; Use of opioid medications in the past 30 days.; Pregnancy.