What this study is
The goal of this clinical study is to test whether a structured prehabilitation program can be successfully used by adults with pancreatic cancer who are receiving chemotherapy before planned surgery. Prehabilitation is a program designed to improve a person's physical fitness, nutrition, and symptom control before surgery.
The study's main hypothesis is that patients with pancreatic cancer can take part in and adhere to a multimodal prehabilitation program during chemotherapy, and that doing so may improve physical function, patient experience, and early recovery after surgery.
What's being tested
- Multimodal Prehabilitation
Intervention · BEHAVIORAL
Participants will receive a structured, multimodal prehabilitation program delivered during neoadjuvant chemotherapy prior to planned pancreatic cancer surgery. The program integrates supervised, individualized exercise training, nutritional assessment and counseling with recommended preoperative immunonutrition, and supportive care focused on symptom management and functional support. Prehabilitation is delivered as an integrated component of preoperative care and continues through completion of neoadjuvant therapy until surgery.
Study details
- Official title
- Multimodal Prehabilitation Prior to Pancreatic Cancer Surgery: A Pilot Study
- Sponsor
- University of Massachusetts, Worcester
- Conditions
- Pancreatic Cancer, Adult · Prehabilitation
- Enrolling
- 20 people
- Starts
- 2026-03-31
- Est. completion
- 2028-12
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Age ≥ 18 years
- Diagnosis of pancreatic ductal adenocarcinoma (PDAC)
- Planned neoadjuvant chemotherapy prior to planned surgical resection
- Medically stable and cleared to participate in physical activity/exercise programming
- Able to provide informed consent
- Ability to read, write and understand English
You can't join if
- Age <18 years
- Pregnant
- Prisoner
- Severe cognitive impairment that precludes informed consent or participation
- Contraindications to physical activity, including unstable cardiac disease, severe pulmonary disease, or recent myocardial infarction
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUMass Memorial Medical Center
Worester, Massachusetts, United States
- Kayla R Widdowson, MD · Contact774-641-1257kayla.widdowson@umassmed.edu
Recruiting
Study team
Sponsor
University of Massachusetts, Worcester
Study ID STUDY00002524
Principal investigator
James M Lindberg, MD
UMass Memorial Health
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.