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Lumbar RadiculopathyPainDrugPhase 4

What this study is

This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and function in lumbar radiculopathy at varying doses, and to evaluate difference in efficacy between triamcinolone and dexamethasone interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, with the overarching hypotheses that there is no difference in reported pain reduction, quality of life, or function among patients receiving low, moderate, or high doses, and no difference in reported pain reduction between triamcinolone and dexamethasone.

What's being tested

  • Triamcinolone 10 Mg/mL Injectable Suspension

    Intervention · DRUG

    A single 10 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

  • Triamcinolone 40 Mg/mL Injectable Suspension

    Intervention · DRUG

    A single 40 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

  • Triamcinolone 80 Mg/mL Injectable Suspension

    Intervention · DRUG

    A single 80 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

  • Dexamethasone 2 MG

    Intervention · DRUG

    A single 2 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

  • Dexamethasone 4mg

    Intervention · DRUG

    A single 4 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

  • Dexamethasone 8 MG

    Intervention · DRUG

    A single 8 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

Study details

Official title
Dose Dependent Response to Interlaminar Steroid Injections for Lumbar Radiculopathy
Sponsor
University of Miami
Conditions
Lumbar Radiculopathy · Sciatica · Back Pain With Radiation
Enrolling
150 people
Starts
2026-09-15
Est. completion
2027-05
Design
Single-blind, randomized, parallel groups, Phase 4
Record
View on ClinicalTrials.gov ↗