What this study is
The goal of this randomised control trial is to measure the gut microbiome response to long-haul travel alongside the demands of pre-season amongst elite football players. The efficacy of a probiotic in modulating the gut microbiome to mitigate the detrimental impacts of long-haul travel as well as training in the heat will also be explored.
The main questions this study aims to answer are:
- How is the gut microbiome of the professional football player impacted by long-haul travel during the pre-season period?
- How is immune function impacted by the demands of pre-season?
- Can a probiotic dietary maintain gut microbial stability in response to long-haul travel? Researchers will compare the effects of the probiotic supplement with a placebo.
Participants will be required to:
- Provide a faecal sample at multiple points throughout the pre-season
- Provide a saliva sample at multiple points throughout the season
- Consume a daily supplement which will either be a placebo or probiotic capsule
What's being tested
- Probiotic Capsule
Intervention · DRUG
Probiotic capsule administered orally once daily for 3 weeks
- Placebo
Intervention · DRUG
Placebo tablet, identical in appearance to probiotic, administered orally once daily for 3-4 weeks.
Study details
- Sponsor
- Sheffield Hallam University
- Conditions
- Microbial Composition · Immune Function
- Enrolling
- 30 people
- Starts
- 2025-07-25
- Est. completion
- 2026-08-15
- Design
- Single-blind, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 40 YearsSex MALEHealthy volunteers AcceptedYou may qualify if
- Male professional footballers who are involved in regular training during the pre-season period.
- Generally healthy, with no acute or chronic illnesses that could interfere with the study intervention or outcomes.
- Not currently consuming probiotics, prebiotics, or antibiotics within 4 weeks prior to enrolment.
- Willing to refrain from starting any new dietary supplements or probiotics during the study period.
- Able and willing to provide written informed consent.
You can't join if
- History of gastrointestinal disorders (e.g., Crohn's disease, ulcerative colitis, irritable bowel syndrome) or chronic diseases that could interfere with probiotic metabolism or study outcomes.
- Acute illness (e.g., infection) within 2 weeks prior to enrollment.
- Known allergy or hypersensitivity to components of the probiotic or placebo. - - - Use of antibiotics, probiotics, prebiotics, or synbiotics within 4 weeks prior to study start.
- Use of immunosuppressive medications or other supplements likely to impact gut microbiota.
- Regular use of alcohol or drugs at levels that could interfere with study participation or outcomes.
- Participation in another clinical trial within the past 3 months.
- Any injury or medical condition that limits participation in full training or matches during the study period.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 open1 Hotel Nashville
Nashville, Tennessee, United States
1 site outside the US
Bodymoor Heath
Tamworth, West Midlands, United Kingdom
Study team
Sponsor
Sheffield Hallam University
Study ID ER79032366
Principal investigator
George Davis, Masters
Sheffield Hallam University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.