What this study is
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
What's being tested
- Macupatide
Intervention · DRUG
- Eloralintide
Intervention · DRUG
- Placebo
Intervention · DRUG
All interventions
Administered SC
Study details
- Official title
- A Phase 2b, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes
- Sponsor
- Eli Lilly and Company
- Conditions
- Overweight · Obesity
- Enrolling
- 400 people
- Starts
- 2026-05-15
- Est. completion
- 2028-02
- Design
- Double-blind, randomized, parallel groups, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 75 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- See Master Protocol CWMM (NCT06143956) for inclusion criteria
You can't join if
- In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):; Have type 1 diabetes or type 2 diabetes; Have an ongoing history of bradyarrhythmia and/or sinus bradycardia; Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm); Have a history of acute or chronic pancreatitis; All concomitant medications should be at a stable dose for at least 3 months prior to screening
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (40)
40 openThe Institute for Liver Health II dba Arizona Clinical Trials - Mesa
Chandler, Arizona, United States
- Yessica Sachdeva · Principal investigator
RecruitingHeadlands Research - Scottsdale
Scottsdale, Arizona, United States
- Benjamin Clark · Principal investigator
RecruitingThe Institute for Liver Health II dba Arizona Liver Health-Tucson
Tucson, Arizona, United States
- Anita Kohli · Principal investigator
RecruitingNorCal Medical Research, Inc
Greenbrae, California, United States
- Linda Gaudiani · Principal investigator
RecruitingVelocity Clinical Research, Huntington Park
Huntington Park, California, United States
- Stanley Hsia · Principal investigator
RecruitingPeninsula Research Associates
Rolling Hills Estates, California, United States
- LeighAnn Schmidt · Principal investigator
RecruitingDiablo Clinical Research, Inc.
Walnut Creek, California, United States
- Bonnie Kimmel · Principal investigator
RecruitingStamford Therapeutics Consortium
Stamford, Connecticut, United States
- David Radin · Principal investigator
RecruitingNew Horizon Research Center
Miami, Florida, United States
- Lazaro Nunez · Principal investigator
RecruitingIndago Research & Health Center, Inc
Miami Lakes, Florida, United States
- Jose Cardona · Principal investigator
RecruitingSuncoast Clinical Research, Inc.
New Port Richey, Florida, United States
- Cathy Barnes · Principal investigator
RecruitingCharter Research - Winter Park
Orlando, Florida, United States
- Edgardo Rivera-Rivera · Principal investigator
RecruitingCharter Research - Lady Lake
The Villages, Florida, United States
- Jeffrey Norton · Principal investigator
RecruitingMedical Research Partners
Ammon, Idaho, United States
- Joseph Moore · Principal investigator
RecruitingGreat Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
- Rupal Trivedi · Principal investigator
RecruitingCotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
- susan brian · Principal investigator
RecruitingMonroe Biomedical Research - Louisville
Louisville, Kentucky, United States
- Harold Bays · Principal investigator
RecruitingKnownwell
Needham, Massachusetts, United States
- Angela Fitch · Principal investigator
RecruitingLucida Clinical Trials
New Bedford, Massachusetts, United States
- David Shih · Principal investigator
RecruitingHeadlands Research - Detroit
Southfield, Michigan, United States
- Christopher Romero · Principal investigator
RecruitingArcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States
- Neil Fraser · Principal investigator
RecruitingStudyMetrix Research
City of Saint Peters, Missouri, United States
- Timothy Smith · Principal investigator
RecruitingClinvest Headlands Llc
Springfield, Missouri, United States
- Christina Capps · Principal investigator
RecruitingLas Vegas Medical Research
Las Vegas, Nevada, United States
- Cornell Calinescu · Principal investigator
RecruitingDent Neurologic Institute
Amherst, New York, United States
- Laszlo Mechtler · Principal investigator
RecruitingRochester Clinical Research, LLC
Rochester, New York, United States
- Patrick Connors · Principal investigator
RecruitingMedication Management
Greensboro, North Carolina, United States
- James Franklin · Principal investigator
RecruitingMonroe Biomedical Research
Monroe, North Carolina, United States
- Awawu Igbinadolor · Principal investigator
RecruitingLucas Research, Inc
Morehead City, North Carolina, United States
- Kathryn Lucas · Principal investigator
RecruitingLucas Research, Inc.
New Bern, North Carolina, United States
- Joseph Maides · Principal investigator
RecruitingCTI Clinical Research Center
Cincinnati, Ohio, United States
- James Maynard · Principal investigator
RecruitingTribe Clinical Research, LLC
Greenville, South Carolina, United States
- Ronald Mayfield · Principal investigator
RecruitingQuality Medical Research
Nashville, Tennessee, United States
- Saras Sharma · Principal investigator
RecruitingIMA Clinical Research Austin
Austin, Texas, United States
- Nomita Kim · Principal investigator
RecruitingFutureSearch Trials of Dallas
Dallas, Texas, United States
- Michael Downing · Principal investigator
RecruitingPlanIt Research, PLLC
Houston, Texas, United States
- Amer Al-Karadsheh · Principal investigator
RecruitingEndeavor Clinical Trials
San Antonio, Texas, United States
- Nitendra Agarwal · Principal investigator
RecruitingTexas Valley Clinical Research
Weslaco, Texas, United States
- Eduardo Luna · Principal investigator
RecruitingSovah Clinical Research-River District
Danville, Virginia, United States
- Stephan Jannach · Principal investigator
RecruitingCentral Washington Health Services Association d/b/a Confluence Health
Wenatchee, Washington, United States
- Kathryn Eren · Principal investigator
Recruiting
Study team
Sponsor
Eli Lilly and Company
Study ID 27844
Study director
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
CONTACT
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
Physicians interested in becoming principal investigators please contact
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.