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ObesityWeight lossNutrition and dietMetabolicHormones and endocrineDrugPhase 3

What this study is

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes.

About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe.

People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

What's being tested

  • PF-08653944

    Intervention · DRUG

  • Placebo

    Intervention · OTHER

Both interventions

By Subcutaneous Injection

Study details

Official title
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY PF-08653944 IN ADULTS WITH OVERWEIGHT OR OBESITY (VESPER-6)
Sponsor
Pfizer
Conditions
Obesity · Overweight and/or Obesity · Overweight
Enrolling
954 people
Starts
2026-06-10
Est. completion
2028-06-21
Design
Double-blind, randomized, parallel groups, Phase 3
Record
View on ClinicalTrials.gov ↗