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ObesityPeptides and GLP-1Weight lossDrugPhase 1

What this study is

The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participant will get is decided by chance. The study will last for about 8 months.

What's being tested

  • Cagrilintide

    Intervention · DRUG

    Cagrilintide will be administered subcutaneously.

  • Placebo (matched to Cagrilintide)

    Intervention · DRUG

    Placebo matched to Cagrilintide will be administered subcutaneously.

Study details

Official title
Tolerability of Cagrilintide in People With Obesity That Discontinued GLP-1-RA Therapies Due to Gastrointestinal Adverse Events: a Double-blinded Randomised Feasibility Study
Sponsor
Novo Nordisk A/S
Conditions
Obesity · Overweight
Enrolling
114 people
Starts
2026-05-29
Est. completion
2027-11-19
Design
Quadruple-blind, randomized, parallel groups, Phase 1
Record
View on ClinicalTrials.gov ↗