Mezagitamab for late antibody-mediated rejection after a kidney transplant

You may qualify if

• The participant aged 18 to 80 years.
• The participant must have a biopsy-confirmed diagnosis of active or chronic active late AMR (defined as greater than [>] 6 month after kidney transplant) without concurrent definitive TCMR (Grade 1a and above) as defined by the 2022 Banff classification.
• Biopsy within 30 days prior to screening, or performed during screening period within protocol-defined window.
• If the participant has received treatment for rejection, then the repeat biopsy and donor specific antibody (DSA) testing must have been performed at least 6 weeks after stopping the treatment.
• The participant with either human leukocyte antigen (HLA) class I and/or II DSA.
• eGFR > 30 milliliters per minute per 1.73 square meters (mL/min/1.73m^2).

You can't join if

• The participant has blood type A, B, AB, or O (ABO) incompatible transplant.
• The participant has a history of multiple organ transplants, including en bloc and dual kidney transplants.
• Participant likely to require renal replacement therapy within the subsequent 30 days.
• Participants who have received an anti-cluster of differentiation 38 (CD38) therapy in the last 1 year or have past history of failing to achieve AMR resolution despite treatment with an anti-CD38 therapy.
• The participant has received any previous treatment with other immunosuppressant or immunomodulatory therapy: a) Within 6 months of signing the informed consent form (ICF) as listed below:; Complement system inhibitors (such as, eculizumab).; Proteasome inhibitors (such as, bortezomib).; Interleukin-6 (IL-6)/IL-6R antibody (such as, tocilizumab).; Anti-cluster of differentiation 20 (CD20) antibody (such as, rituximab). b) Within 6 weeks of signing the ICF as listed below:; Intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG) or plasmapheresis
• The participant has active infection with hepatitis B virus, hepatitis C virus (HCV), or human immunodeficiency virus (HIV).
• Participant with serious infection within 2 weeks or with opportunistic infection within 2 months prior to signing ICF. Participant with active or untreated tuberculosis, or those with high suspicion of tuberculosis are also excluded.
• History of malignancy (including myelodysplastic syndrome) within 5 years of signing the ICF, except for adequately treated non-melanoma skin cancer, superficial bladder cancer, and curatively treated cervical carcinoma-in-situ. Key Note: Other protocol specified inclusion and exclusion criteria apply.