What this study is
Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.
What's being tested
- Multisensory Rehabilitation
Intervention · BEHAVIORAL
12 research sessions + clinical visits at the time of the first and last session - In each session, there will be a "training phase" in which subjects will be exposed (and respond) to spatiotemporally congruent pairs of visual-auditory stimuli presented within their blinded field, with occasional probes of unisensory visual stimuli on both sides of space. There will also be a "testing" phase during which they are presented with visual stimuli in virtual reality (VR) to assess multiple aspects of visual function. This "visual battery" consists of innocuous stimuli, e.g., flashes of light or moving bars, presented at intensities consistent with those experienced during daily life. Subjects detect or discriminate the stimuli (e.g., judge whether a stimulus was flashed, or which stimulus is brighter) and report confidence in assessments.
Study details
- Sponsor
- Wake Forest University Health Sciences
- Conditions
- Cortical Blindness
- Enrolling
- 30 people
- Starts
- 2027-01
- Est. completion
- 2028-03
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 85 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Patients will be recruited from the local subject population hospitalized/seen by Ophthalmology, Neurosurgery, and Neurology at Atrium Health Wake Forest Baptist
- Diagnosis of stable homonymous hemianopia (>4 weeks) with absence of hemineglect
- A lesion encompassing at least primary visual cortex but sparing parietal cortex, to include lesions caused by an ischemic or hemorrhagic stroke or post-surgical changes due to an oncologic or non-oncologic tumor
- Normal or correctable auditory and cognitive function
- Willingness to participate in the three-month program
- Ability to perform visual discriminations in their intact field
- Life expectancy ≥12 months
You can't join if
- Diagnosis of an unstable homonymous hemianopia and/or with hemineglect,
- Abnormal or uncorrectable auditory and cognitive function
- Unwillingness to participate in the program
- Inability to perform the visual testing in their intact field
- Life expectancy < 12 months
- Any other condition that would compromise their ability to complete the study.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openWake Forest University Health Sciences
Winston-Salem, North Carolina, United States
- Wendy Jenkins, BSNRN, CCRC · Contact336-716-3842Wendy.Jenkins@AdvocateHealth.org
Study team
Sponsor
Wake Forest University Health Sciences
Study ID IRB00151786
Principal investigator
Benjamin Rowland, PhD
Wake Forest University Health Sciences
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.