What this study is
Many Veterans who are hospitalized with heart failure do not receive all the recommended heart medications at the right doses before they leave the hospital or in the weeks following discharge. This study tests whether a team of clinical pharmacists and cardiologists, working virtually, can improve heart failure medication prescribing for Veterans at VA medical centers. The pharmacist and cardiologist team reviews patient records and provides recommendations to the treating doctors and primary care providers caring for Veterans with heart failure. The goal is to increase use of guideline-recommended medications, which have been shown to improve survival, reduce hospitalizations, and improve quality of life.
What's being tested
- Pharmacist/Cardiologist Virtual Team Digital Consultation
Intervention · BEHAVIORAL
A centralized pharmacist and cardiologist virtual team (hub) provides protocol-based digital consultation notes to inpatient and outpatient providers(spoke) regarding initiation and intensification of guideline-directed medical therapy (GDMT) for heart failure during hospitalization and the post-discharge transitional care period. Eligible Veterans are identified via VA dashboards and community care claims data. Recommendations cover quadruple therapy (beta blockers, ACEI/ARB/ARNI, MRA, SGLT2i) and are tailored to individual clinical presentations. The pharmacist arranges outpatient follow-up and delivers medication adherence education.
Study details
- Official title
- Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure (PATRIOT-HF) (QUE 25-018)
- Sponsor
- VA Office of Research and Development
- Conditions
- Heart Failure · Heart Failure, Systolic
- Enrolling
- 585 people
- Starts
- 2026-11-01
- Est. completion
- 2030-09-30
- Design
- Open-label, randomized, sequential groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Admission to a VA medical center or VA-paid community hospital within the preceding 3 months with a primary diagnosis of heart failure; The primary study cohort will consist of those admitted to a VA medical center, while the secondary study cohort will consist of patients admitted to VA-paid community hospitals
- Left ventricular ejection fraction ≤ 40%
- Not on optimal guideline-directed heart failure medication classes or doses, as assessed in the electronic health record
- Receiving care within one of the 6 participating VA medical centers
You can't join if
- Hemodynamic instability
- Receiving comfort care measures alone or enrolled in hospice
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openRocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, Colorado, United States
- Paul L Hess, MD MS · Contact(720) 857-6889paul.hess@va.gov
- Paul L Hess, MD MS · Principal investigator
Study team
Sponsor
VA Office of Research and Development
Study ID QUX 26-006
Principal investigator
Paul L Hess, MD MS
Rocky Mountain Regional VA Medical Center, Aurora, CO
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.