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Healthy volunteersDrugPhase 1

What this study is

This study will evaluate the safety, pharmacokinetics (PK), and activity of single and multiple doses of RO7890597 compared with placebo in healthy volunteers. The study includes single ascending dose (SAD) stage, multiple ascending dose (MAD) stage, food-effect and proton pump inhibitor (PPI) stages, and a supplemental drug-drug interaction (DDI) stage.

What's being tested

  • RO7890597

    Intervention · DRUG

    Participants will receive RO7890597 as per the schedule described in the protocol.

  • Placebo

    Intervention · DRUG

    Participants will receive matching placebo as per the schedule described in the protocol.

  • Rabeprazole

    Intervention · DRUG

    Participants will receive rabeprazole as per the schedule described in the protocol.

  • Itraconazole

    Intervention · DRUG

    Participants will receive itraconazole as per the schedule described in the protocol.

Study details

Official title
A Phase I Study to Evaluate the Safety and Pharmacokinetics of RO7890597 Following Single and Multiple Ascending Doses, and the Effects of Food, Proton-Pump Inhibition, And CYP3A Inhibition in Healthy Adult Volunteers
Sponsor
Genentech, Inc.
Conditions
Healthy Volunteers
Enrolling
139 people
Starts
2026-08-28
Est. completion
2027-06-08
Design
Double-blind, randomized, sequential groups, Phase 1
Record
View on ClinicalTrials.gov ↗