TMS for chronic pain

You may qualify if

• Participant must be willing to comply with all study procedures and be available for the duration of the study.
• Male and female patients of 18 years of age or older.
• Diagnosed with peripheral or central neuropathic pain of at least three months duration and phenotyped by the PRC under protocol 16-AT-0077, and on a stable pain medication regimen
• In stable health as determined by study personnel, and without acute medical or mental illness for the past six weeks

You can't join if

• Concurrent epilepsy or history of seizure in the last year
• Inability to provide informed consent
• Ferromagnetic metal in the cranial cavity or eye, implanted neural stimulator, cochlear implant, or ocular foreign body
• Implanted electronics contraindicated for MRI or TMS, such as cardiac pacemaker or auto-defibrillator or pumps
• Non-removable body piercings
• Claustrophobia severe enough to preclude MRI
• Inability to lie supine for 1 hour
• Members of the NINDS BNU or NIHPRC
• Individuals with elevated risk and potential contraindications to MRI, as defined by the NIH NMR center guidelines.
• Known hearing loss, as assessed by asking the potential participant whether they have hearing loss
• Have difficulties with communication that make subjective pain assessment impossible or unreliable
• Have active medical or psychiatric health issues that create additional and substantial adverse risks related to study procedures
• Pregnant participants or participants planning to become pregnant during the study. At enrollment/baseline, pregnancy status will be assessed by asking participants capable of becoming pregnant whether they are pregnant or planning to become pregnant during the study. Before each fMRI, participants capable of becoming pregnant must have a negative urine pregnancy test to continue with the fMRI.