Real-time MRI neurofeedback for working memory in childhood medulloblastoma survivors

You may qualify if

• Age ≥ 10 and ≤ 25 years at the time of enrollment.
• English as a primary language.
• Current St. Jude participants who received treatment for medulloblastoma with upfront craniospinal radiotherapy (proton or photon), inclusive of SJMB12 participants and those treated as per SJMB12 at least 2 years from completion of treatment of their medulloblastoma.
• Demonstrate working memory impairment based on age-appropriate questionnaire electronically administered pre-enrollment. Specifically, scores >57 on the Working Memory Index of the BRIEF (places the individual in the top 25% of people who have difficulty with working memory tasks).

You can't join if

• History of seizures, on or off antiepileptic drugs, in the past 3 months.
• A premorbid history of significant neurological disease, including stroke or head injury with loss of consciousness.
• A psychiatric condition that would preclude or take precedence over study participation (e.g., active psychosis, suicidal ideation).
• Major sensory or motor impairment that would preclude valid cognitive testing secondary to inability to complete study procedures (e.g., blindness, paresis).
• IQ < 70 based on standardized testing routinely conducted on primary treatment protocols or as part of the New Oncology Program in Psychology (NOPP).
• Metal or surgical implants that would prevent MRI scanning.
• Inability or unwillingness of research participant or legal guardian/ representative to give written informed consent.
• Pregnancy. The St. Jude IRB requires that a female participant of childbearing potential (generally >10 yrs. old) must have a negative pregnancy test as a condition of clinical research eligibility.
• Permanent orthodontic retainers or braces-shunt, anything else that would not be a safety risk but would impact image quality.