Ear nerve stimulation (Cymbathera One System) to reduce eye inflammation

You may qualify if

• Age ≥18 years
• Ocular inflammatory condition-specifically, at least 1 eye with intra/subretinal fluid or both eyes with an inflammatory ocular surface condition
• Able to attend all study visits at approximately the same time of day (within a 3-h window) For participants in the intra/subretinal fluid group:; The presence of a natural crystalline lens or intraocular lens; Pupils that can dilate to at least 3 mm in the study eye(s); The absence of opaque natural crystalline lenses or the presence of any ocular disease that prevents the view of the retina for imaging

You can't join if

• Having or exhibiting any of the following:; Evidence of active infection; Chronically implanted electronic medical device, including pacemakers, defibrillators, cochlear implants, spinal stimulators, and vagus nerve stimulators; Evidence of any skin condition at the stimulation site; Untreated or poorly controlled psychiatric illness; Evidence of significant neurological conditions, including multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, seizure, stroke, and dementia; Low blood pressure, bradycardia, or hypoglycemia; History of bleeding disorders, including sickle cell anemia, anemia syndromes, monocytosis, and thrombocytopenia; History of vagotomy; History of partial or complete splenectomy; History of HIV infection or AIDS; History of recurrent vasovagal syncope episodes
• Receipt of any of the following medications within 1 week of the first visit:; Anticholinergic (Benadryl); Antihypertensive (α-methyldopa); Epinephrine-related drugs, norepinephrine-related drugs, and drugs that stimulate release of epinephrine and/or norepinephrine (Micronefrin, Asthmanefrin); Alpha and/or beta adrenoceptor blocking agents; Antiseizure medications; Other medications, supplements, etc. that may interfere with the study results
• Substance abuse (alcoholism or other) problem
• Consumption of alcohol within 1 day of a study visit
• Currently using or have used recreational drugs, tobacco, and/or nicotine products within 1 week of the first visit