What this study is
This study is being done to see which of two common grafting techniques-mixing two different grafting materials or layering two grafting materials-works better to augment bone volume next to participant's dental implant(s). The investigators want to know which technique results in better bone augmentation.
What's being tested
- Sandwich bone augmentation
Intervention · PROCEDURE
The exposed threads on the buccal side of the implant will be grafted with three distinct layers of grafting materials.
- Mixed bone augmentation
Intervention · PROCEDURE
The exposed threads on the buccal side of the implant will be grafted with three grafting materials mixed together.
Study details
- Official title
- Comparison of Dental Implant Placement With Simultaneous Sandwich Bone Augmentation vs. Mixed Bone Augmentation: a Randomized Controlled Pilot Study
- Sponsor
- University of California, San Francisco
- Conditions
- Peri-implant Bone and Soft Tissues
- Enrolling
- 30 people
- Starts
- 2026-11-01
- Est. completion
- 2028-12-31
- Design
- Double-blind, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Minimum dentition of 20 permanent teeth
- Single edentulous site at maxillary premolar, canine, lateral incisor, or central incisor
- Adjacent teeth present with sufficient clearance for an implant crown
- Ridge width between 4 mm and 7 mm at the edentulous site
You can't join if
- Systemic criteria:
- Current heavy smokers (>10 cigarettes per day) or heavy smokers who quitted less than 1 year
- Pregnancy or lactating mothers
- Diseases of the immune system or any medical condition that may influence the treatment outcome (for examples uncontrolled diabetes (HbA1c >7), uncontrolled cardiovascular disease, neurologic or psychiatric disorders, systemic infections, history of radiation therapy in the head and neck area, current use of oral bisphosphonates for >3 years or history of IV bisphosphonates use, current alcoholism or drug abuse, etc.)
- Intraoral criteria:
- Acute infection at/or adjacent to the edentulous site (e.g., sinus tract, swelling, etc.)
- Observable gingival changes due to use of medications such as calcium antagonists, anticonvulsives, immunosuppressants, anti-inflammatory medications, etc.)
- Generalized uncontrolled dental diseases, e.g. caries, periodontal diseases, etc.
- Uncontrolled periodontal disease
- Poor oral hygiene (>20% plaque score)
- CBCT criteria:
- More than 7 mm of alveolar ridge with at the edentulous site present on CBCT scans
- Intraoperative criteria:
- An implant without primary stability >35N
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openPeriodontology Clinic, UCSF School of Dentistry
San Francisco, California, United States
- Guo-Hao Lin, DDS, MS · Contact415-476-1731
Study team
Sponsor
University of California, San Francisco
Study ID 26-46484
Principal investigator
Guo-Hao Lin, DDS, MS
University of California, San Francisco
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.