What this study is
The work will examine the mechanisms and potential therapeutic effects of transcranial magnetic stimulation on upper-limb sensorimotor function in individuals with cerebellar dysfunction, including those with damage due to stroke or autoimmune disease.
The study team will work toward a goal of non-invasive stimulation-based neuromodulatory interventions for cerebellar disorders using a closely integrated, clinically oriented cross-species approach. There will be a related study in nonhuman primates.
What's being tested
- Transcranial Magnetic Stimulation
Intervention · DEVICE
Stimulation of continuous theta burst stimulation at 80% of resting motor threshold over the region targeted for modulation after behavioral testing, with resting of behavior afterwards.
Study details
- Official title
- Neuromodulation of Cerebellar Circuitry
- Sponsor
- George Wittenberg
- Conditions
- Cerebellar Stroke · Autoimmune Cerebellar Disorders
- Enrolling
- 60 people
- Starts
- 2026-12
- Est. completion
- 2028-12
- Design
- Single-blind, randomized, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 100 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- 18-100 years old,
- Native English speakers,
- Medically stable to participate in the study. For those with cerebellar disorders:; presenting with a cerebellar disorder including cerebellar stroke; cerebellar disorder onset at least 2 weeks before enrollment.
You can't join if
- Are unable to give consent,
- Have contractures, orthopedic problems, or other impairments that would interfere with the use of the robot or limit the range of joint motion in the potential study arm,
- Presence of medical condition or implant that prevents safe administration of stimulation (history of seizures, and/or taking any of the following medications: lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), topiramate (Topamax), phenytoin (Dilantin), arbamazepine (Tegretol), valproic acid (Depakote), or phenobarbital (Barbita, Luminal, Solfoton).
- Have any factor that precludes participation in a magnetic resonance imaging (MRI) session (e.g. ferrous metal in the body), or
- Have a medical condition or physical impairment precluding the ability of the participant to complete the required testing.
- Are pregnant Control participants will be excluded for the following condition:; have self-reported history of neurological injury or a developmental disorder
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of Pittsburgh
Pittsburgh, Pennsylvania, United States
Study team
Sponsor
George Wittenberg
Study ID STUDY26050032
Study director
Jorge A González-Martinez, MD, PhD
University of Pittsburgh
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.