Comparing psilocybin doses and alcohol for their intoxicating and impairing effects

You may qualify if

• Be at least 21 years old,
• Be in good general health based on screening procedures (e.g., physical exam, blood testing, psychiatric evaluation),
• Have vital signs in normal range,
• Have not donated blood in past 30 days,
• Not be pregnant (assessed via blood serum at screening and urinalysis before each study session) or breast feeding (women only),
• Have a body mass index (BMI) in the range of 18 to 36 kg/m2,
• Report using psilocybin at least once in the participant's lifetime, but not in the past month,
• Negative urine test for illicit drug use (not including cannabis) and negative breath alcohol test (0% breath alcohol concentration) at screening and before study sessions.

You can't join if

• Psychoactive drug use (aside from nicotine, alcohol, caffeine, cannabis) in past month,
• Current use of over the counter (OTC) drugs, supplements/vitamins, or prescription medications that, in the opinion of the investigator or medical staff, will impact the participant's safety,
• History of or current evidence of significant medical condition that would impact participant's safety (e.g., hypertension, epilepsy),
• Evidence of current psychiatric condition (based on MINI),
• Family history of 1st degree relative with psychotic disorder or bipolar 1 disorder,
• Clinical institute withdrawal assessment for alcohol-revised (CIWA-Ar) score >9 (which indicates that severe withdrawal),50
• Enrollment in another clinical trial or receiving of any drug as part of research within past 30 days, and
• Shipley vocabulary score <18 (corresponds to 5th grade reading level).