What this study is
Simplified from ClinicalTrials.govTesting an antiseptic called povidone iodine, applied inside a dental implant, to see whether it reduces or changes the bacteria inside the implant, which might lower implant failure, bone loss, and infection. It is for adults ages 18 to 55 getting two new dental implants, with the antiseptic placed in one implant and not the other.
Read the original summary from ClinicalTrials.gov
We hope to learn if applying antiseptic to the inside of a dental implant will decrease or alter the types of bacteria inside it which may then decrease the incidence of implant failure associated with bone loss, infection, and other complications. During your implant placement appointment, an antiseptic (povidone iodine) will be applied to the inside one of your two new dental implants, no antiseptic will be applied to your other dental implant (this is what would occur if you choose not to participate in this study), before covering both of them with a cover screw or healing abutment. You will return to the Madigan Oral \& Maxillofacial Surgery Clinic 3-6 months later when your implant hardware is removed a swab of the implants internal cavities will be collected. Your participation in this research will last up to 6 months and require one additional minute during both your implant placement and hardware removal appointments.
What's being tested
- Povidone-Iodine
Intervention · DRUG
All participants will receive this intervention in one implant and no intervention in a second implant.
Study details
- Sponsor
- Madigan Army Medical Center
- Conditions
- Dental Implant
- Enrolling
- 60 people
- Starts
- 2026-12-01
- Est. completion
- 2027-09-01
- Design
- Open-label, single group, Phase 1, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 55 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Active Duty Military
- 18-55 years old
- Over 6 months remaining at local duty station (Joint Base Lewis McChord)
- Will be undergoing surgery to receive at least two dental implants
You can't join if
- Tobacco user
- Taking medications affecting soft tissue or bone healing (e.g., IV bisphosphonates)
- Metabolic disorder affecting soft tissue or bone healing (e.g., diabetes where AIC is above 7.0)
- Active periodontal disease
- Pregnant at time of enrollment (these surgeries are not typically performed on pregnant women)
- Known or suspected allergy to OR previous adverse reaction to povidone iodine
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openMadigan Army Medical Center
Tacoma, Washington, United States
- Zachary Colburn, PhD · Contact253-968-3455zachary.t.colburn.civ@health.mil
Study team
Sponsor
Madigan Army Medical Center
Study ID 226117
Principal investigator
Kevin Smith, DMD, FACS
Madigan Army Medical Center
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.