What this study is
Simplified from ClinicalTrials.govTesting methadone (a pain medicine) to see if it controls pain better than the usual pain care in adults 18 and older having minimally invasive lung resection surgery (surgery to remove part of the lung).
Read the original summary from ClinicalTrials.gov
This study is being done to find out if methadone is more effective in controlling pain in patients presenting for minimally invasive lung resection surgery compared to the standard of care.
What's being tested
- Methadone
Intervention · DRUG
intraoperative methadone 0.1mg/kg on induction, based on actual body weight, maximum of 10 mg
- Standard of Care
Intervention · DRUG
any standard of care analgesic at discretion of the anesthesia team not including methadone
Study details
- Sponsor
- Wake Forest University Health Sciences
- Conditions
- Pain Management
- Enrolling
- 150 people
- Starts
- 2026-12
- Est. completion
- 2028-06
- Design
- Double-blind, randomized, parallel groups, Phase 4
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Scheduled for minimally-invasive lung resection surgery (for example, wedge, lobe, segmentectomy, combination of aforementioned procedures)
- Elective same day admission cases
You can't join if
- Daily use of >/= 60 MME for 1 month or greater
- Weight < 50 kg
- Baseline oxygen requirement
- Chronic Kidney Disease Stage 4 or 5
- Diagnosis of cirrhosis or liver failure
- Left ventricular ejection fraction < 30%
- Conversion to thoracotomy
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openAtrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States
Study team
Sponsor
Wake Forest University Health Sciences
Study ID IRB00155968
Principal investigator
Rohesh Fernando, MD
Atrium Health Wake Forest Baptist
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.